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Thiazolidinediones (TZDs) such as pioglitazone can also interact poorly with semaglutide, causing fluid retention or worsening heart failure symptoms in susceptible individuals

Antioxidants (Basel, Switzerland), 2021, 10(12):1864

For a full breakdown of what this peptide does, see our IGF-1 LR3 benefits guide

Some studies show attenuation of NO overproduction in inflammatory states

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