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SGLT2 Inhibitors The EMPA-REG OUTCOME and CANVAS studies have shown favourable all-cause mortality and cardiovascular outcomes.11,12 Meta-analyses of CVOTs confirmed the cardiovascular benefits.17,18 Three studies from landmark CVOTs further stratified patients according to baseline characteristics.21,22,23 The benefits of SGLT2 inhibitors were more apparent in patients with a history of HF and reduced ejection fraction.22,23 However, baseline risk was higher in this group of patients, possibly accounting for higher absolute risk reductions in cardiovascular outcomes

Vial size directly determines reconstitution volume, dose precision, and protocol durationa 10mg vial reconstituted with 2mL bacteriostatic water yields 5mg/mL concentration, while the same 2mL added to a 15mg vial produces 7.5mg/mL

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This prevents over-ordering and reduces the risk of medications expiring before use

There are real trade-offs