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Both GLP-1 and estrogen act on the hypothalamus to suppress appetite, but through different receptor systems

J Pharmacol Exp Ther 2004

11-17 Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a novel class of medications for weight management that stimulate insulin secretion after an oral glucose load, inhibit the production of glucagon at high blood sugar levels, and decrease pancreatic -cell apoptosis

While semaglutide does not typically affect thyroid hormones, baseline thyroid assessment is prudent given the boxed warning

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[25] [26] mhra.gov.uk