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Third, the most plausible blueprint for a cure involves intelligent Combination Strategies, designing synergistic treatment protocols where a finite course of immunotherapy is deployed to establish a receptive, tolerant immune environment, thereby facilitating the successful engraftment and persistence of gene-edited, immune-resilient beta cells

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Available online at: (Accessed July 10, 2023)

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Given that hypothyroidism has been associated with many deleterious outcomes including higher risk of 1) mortality, 2) cardiovascular disease, 3) impaired health related quality of life, and 4) altered body composition in both non-CKD and CKD patients, future research is needed to establish the appropriate screening, diagnosis, and treatment approaches in these populations

Acta 1830 , 31733181, (2013)