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It is commonly prescribed to prevent stroke and systemic embolism in patients with nonvalvular atrial fibrillation, and to treat or prevent deep vein thrombosis (DVT) and pulmonary embolism (PE)

You can read our article titled The Power of Mito to understand the importance of mitochondrial health , which is the driving force behind this ideation

Glossary Ac acetyl acetyl-CoA acetyl-coenzyme A AKI acute kidney injury AMBRA1 activating molecule in BECN1-regulated autophagy protein 1 AMPK AMP-activated protein kinase ARE antioxidant response element ATP adenosine triphosphate BAX Bcl-2-associated X protein BINP3 B-cell lymphoma 2/adenovirus E1B 19-kDa-interacting protein 3 BINP3L BINP3-like BUN blood urea nitrogen CAPE caffeic acid phenethyl ester CKD chronic kidney diseases CPT1 carnitine O-palmitoyltransferase 1 CPT2 carnitine O-palmitoyltransferase 2 Cytc cytochrome c DKD diabetic kidney disease DRP1 dynamin related protein 1 EGCG epigallocatechin 3-gallate ERRs estrogen-related receptors ESRD end-stage renal diseases ETC electron transport chain FAO fatty acid -oxidation FIS1 fission 1 protein FoxO3a forkhead box class O 3a FUNDC1 FUN14 domain-containing protein 1 GSSG oxidized GSSH GSH glutathione GSPE grape seed proanthocyanidin extract GPX glutathione peroxidases HIF-1 hypoxia-inducible factor-1 IMM inner mitochondrial membrane IRI ischemia-reperfusion injury Keap1 kelch-like erythroid cell-derived protein with CNC homology-associated protein 1 LKB1 liver kinase B1 MiD49 mitochondrial dynamics proteins of 49 MFF mitochondrial fission factor Mfn1 mitofusin 1 mPTP mitochondrial permeability transition pore MQC Mitochondrial quality control NAD + nicotinamide adenine dinucleotide Nrf2 nuclear factor-erythroid-derived 2-like 2 NRF nuclear respiratory factors OMM outer mitochondrial membrane OPA1 optic atrophy 1 OXPHOS oxidative phosphorylation Parkin parkin RBR E3 ubiquitin-protein ligase PA-S14 piericidin analogue S14 PINK1 PTEN-induced kinase 1 PGC-1 PPAR coactivator-1 PPAR peroxisome proliferatoractivated receptor PNS panax notoginseng saponins PPAR peroxisome proliferator-activated receptor- ROS reactive oxygen species SIRT1 sirtuin-1 SIRT3 sirtuin-3 SLC25A20 carnitineacylcarnitine translocase Scr serum creatinine SOD superoxide dismutase TCA tricarboxylic acid TECs tubular epithelial cells TFAM mitochondrial transcription factor A Ub ubiquitin UIRI unilateral ischemia-reperfusion injury UUO unilateral ureteral obstruction

The OARSI scores of A-CDs and AA-CDs were significantly reduced by 42.7% and 76.4%, respectively (Fig

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