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In your brain, GLP-1 reaches the hypothalamus, the region that controls appetite and energy balance

Oral administration of AVE3085 for 7 days increases eNOS expression and activity, reverse eNOS uncoupling, reduces oxidative stress and improve endothelial function in diabetic mice (Cheang et al., 2011)

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4 Study of oxidative effects 4.1 Lipid hydroperoxides 4.1.1 Thiobarbituric acid reactive substances assay The Thiobarbituric Acid Reactive Substances (TBARS) assay is an old but commonly used test to study lipid peroxidation by exploiting the product malondialdehyde (MDA) as a marker of the reaction