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A 2024 study published in JAMA Ophthalmology found that patients prescribed semaglutide had a higher observed risk of NAION compared with patients using non-GLP-1 medications for diabetes or weight loss

172 The challenges in developing these drugs include ensuring that they can effectively mimic the biological activity of large molecule GLP-1RAs while maintaining efficacy and selectivity

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The trial shows that it does

Those medications have active ingredients that help to suppress appetite and curb cravings, including Bupropion, Metformin, Naltrexone and Topiramate with Vitamin B12, according to the company

Important Note: Using Ozempic for weight loss when you dont have diabetes is considered off-label use