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Intranasal delivery extends the effective CNS half life because the peptide is transported directly along olfactory and trigeminal nerve pathways into cerebrospinal fluid and hippocampal interstitial space, bypassing systemic circulation and hepatic metabolism

DEFINITION 11 Research Use Only (RUO) A regulatory designation indicating a product is intended for laboratory research and not for human therapeutic, diagnostic, or veterinary application

Continuing for 1-2 weeks after visible wound closure supports the ongoing remodeling phase where collagen continues maturing

This partially explains why black market and commercial reports of weight loss with AOD-9604 are anecdotal and uncontrolled, and why the controlled Phase 2b trialwhich used subcutaneous injectionshowed no effect

However, it doesn't address the underlying immune dysregulation

10.1074/jbc.M116.762567 J