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prausnitzii was reduced, while Actinomyces , Veillonella , and Escherichia coli were found to be increased compared to healthy individuals

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However, there are still challenges that need to be addressed, such as the optimization of properties, reliable characterization methods, safety evaluation, nanoparticles that might lead to unintended consequences like nano-pollution and cytotoxicity and regulatory aspects related to nanomedicines targeting skin cancer [176, 179]

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Suffice it to say, there is likely a non-negligible portion of the population that is being undertreated if only LDL is used as a target