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Ice crystal formation during freezing can disrupt the tertiary protein structure, potentially reducing potency

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Brazilian Journal of Medical and Biological Research, 36: 1409-1417, 2003

Some factors related to eye health are uncontrollable, however, like genetics and age

There was even a theory originally put out in the 1950s called The Free Radical Theory of Aging* which basically held that we age by rusting from within, due largely (but not exclusively) to free radical damage