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Patients taking GLP-1 agonists most commonly complain of gastrointestinal effects, 2 such as unsettled stomach, upset GI tract, variable bowel movements or trouble with elimination, abdominal discomfort, and gastroesophageal discomfort

One notable approach involves the use of dibenzazepine (DBZ), a -secretase/Notch pathway inhibitor

At present, the studies of EX on non-diabetic obesity mainly include 152 cases of simple obesity (weight loss of 5.1 kg) (54), 60 cases of polycystic ovary syndrome (weight loss of 3.2-6.0 kg) (55), and 10 cases of metabolic syndrome (weight loss of 3.7 kg) (56), among which the most common adverse reaction is still vomiting

J Diabetes Investig (2010) 1:823

Orforglipron is in Phase 3 clinical trials now

8,9,10 These mechanisms make GLP-1RAs powerful tools for controlling blood glucose and improving metabolic syndrome