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2023 NEJM) found semaglutide reduced overall cardiovascular event rates by 20% despite the small HR increase

Lipo C is contraindicated in patients with Lebers hereditary optic neuropathy (cyanocobalamin can worsen this condition), active B12-dependent malignancies, severe kidney disease (impaired methionine clearance), or known hypersensitivity to any component

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There have been several clinical trials with various GLP-1 agonists investigating cardiovascular outcomes in patients being treated for type 2 diabetes 10,11,12,13,14,15,16,17,18,19