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doi: 10.3389/fphar.2022.1016639 61 Tirzepatide

The OCTN subclade, comprised of OCTN1 (SLC22A4) and OCTN2, are a distinct subgroup of OCTs that primarily catalyse the uptake of the zwitterionic metabolites ergothioneine 13 and carnitine respectively, but are also capable of transporting cations such as tetraethylammonium (TEA) 14,15 indicating a potential dual transport function 15,16

Alam M, Hughart R, Champlain A, et al

At the same time, rosmarinic acid promotes the upregulation of TH and brain-derived neurotrophic factor (BDNF) genes to alleviate the cytotoxicity of H 2 O 2 -induced N2A cells (Ghaffari et al., 2014)

doi: 10.1002/art.39785 114 BalakrishnanBLuckeyDBodhkeRChenJMariettaEJeraldoPet al