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The model contains only 13 zonation-dependent kinetic parameters (Supplementary Material), and metabolic zonation was simulated by manually changing enzyme activities depending on the zone that the cell belongs to, either the periportal or pericentral region

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(2) ENS neurological repair via Lion's Mane (NGF stimulation) and ALCAR (neuronal energy and acetylcholine)

Reference: Self-reported side effects of semaglutide and tirzepatide in online communities by Neil K

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