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Tirzepatide is not recommended for people with a family history of thyroid tumors or a family history of medullary thyroid carcinoma (MTC) and MEN2 syndrome (multiple endocrine neoplasia type 2 syndrome), as tirzepatide increases the potential risk of developing these tumors in rodents

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For this reason, supplementation should be approached carefully and individualized

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Until it goes through proper trials and regulatory approval, the risk-benefit math is difficult to evaluate