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Your starting dose and individual sensitivity to the medication play major roles in determining whether you see the lower or higher end of this range

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N Engl J Med 375:18341844 Lincoff AM, Brown-Frandsen K, Colhoun HM et al (2023) Semaglutide and cardiovascular outcomes in obesity without diabetes

The practical differences show up in predictable ways

5, Supplementary Fig

IGF-1R Independent E-Domain Activity In rat H9c2 myocardial-like cells, the E-domain of MGF exerts autonomous IGF-1 receptor-independent actions with treatment of cells showing rapid cellular uptake via a mechanism that did not involve IGF-1 receptor activation, but resulted in nuclear localisation