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Assigning that to MC4R, or MC1R, requires either a system expressing only one receptor subtype, or selective antagonist controls, or a selective agonist comparator run in parallel
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It also plays a key role in neutralizing free radicals, which can cause cellular damage and lead to early signs of aging
10.1016/j.ejphar.2008.06.067 87 SasakiT.SatoY.KumagaiT.YoshinariK.NagataK
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Using both together can significantly increase the risk of increased heart rate, blood pressure, and rarely, serotonin syndrome
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