Phung, N., et al., Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis
Side-by-Side Comparison Table Practical Considerations There are several practical considerations when choosing between these weight loss options
Additional clinical trials are required to evaluate the efficacy, safety, and tolerability of the different GLP-1s for disease management and for reducing cause-specific and all-cause mortality
Preparing PT-141 nasal spray Why nasal spray: Avoids injections (needle-phobic) More convenient Slightly faster onset (30-60 min quicker) Lower bioavailability (~30% vs ~100% injection) Need higher dose to compensate Nasal spray supplies needed: Empty nasal spray bottle (10-15ml) Reconstituted PT-141 (higher concentration recommended) Syringe for transferring Small funnel (optional) Concentration for nasal spray: Higher concentration better (less volume per dose) Reconstitute 10mg PT-141 in 1ml water = 10mg/ml Or even 10mg in 0.5ml = 20mg/ml (very concentrated) Allows smaller spray volume Fewer sprays needed per dose Nasal spray dosing: Inject: 1.5mg dose Nasal equivalent: 3-5mg (lower absorption) 0.3ml of 10mg/ml concentration = 3mg nasal 0.5ml of 10mg/ml = 5mg nasal Typical: 2-3 sprays per nostril (0.1ml per spray) See complete PT-141 nasal spray guide for men for detailed protocols
If life gets in the way and you miss your scheduled injection, taking it within 48 hours of when you were supposed to inject is still considered safe and effective
Genomic analysis of reactive astrogliosis
