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There are multiple drugs producing clinically relevant weight loss 9 , including semaglutide (S)a long-acting glucagon-like peptide-1 (GLP-1) 10 analogue and cagrilintide (C)a long-acting amylin analogue 11

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Under pathological conditions, disruption of TFAM can lead to mtDNA mispackaging, a massive release of damaged mtDNA, and down-regulation of TFAM also reduces the stability of the mtDNA mimetic nuclear structure (West et al., 2015)