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SS-31 goes further it crosses the cell membrane, crosses the mitochondrial outer membrane, and binds directly to cardiolipin on the inner mitochondrial membrane

Eberle D, Hegarty B, Bossard P, Ferre P, Foufelle F (2004) SREBP transcription factors: master regulators of lipid homeostasis

Structural Enhancements: N-acetylated and C-terminal amidated for improved stability and extended activity

Benefits: Potential benefits include increased levels, activation of the longevity gene SIRT1, improved insulin sensitivity, and reversal of diet-induced obesity

Three interconnected pathways function as core suppressors of ferroptosis: (1) the GPX4-GSH system (central suppressor), (2) the SLC7A11-cystine import pathway (GSH synthesis), and (3) the AIF family member 2 (AIFM2, also known as FSP1)-NAD(P)Hquinone pathway (parallel protection) 84-87

However, during fasting, NHR-49 and other key regulators of lipolysis and -oxidation appear dispensable for lifespan extension