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For example, Bifidobacterium animalis F1-7 can upregulate acetylcarnitine levels in the gut, thereby downregulating the TLR4/NF-B pathway and reducing lipid accumulation and inflammation in foam cells, leading to a reduction in atherosclerotic plaque accumulation [129]
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Our overarching framework is that gutbrain (and other periphery-to-brain) endocrine signaling may play a role in AUD (and potentially other substance use disorders) and could therefore represent novel targets for treatment development
Frohman et al
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In obese people, cartilage suffers an additional burden, with the hips and knees being particularly affected
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