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Nevertheless, there is widespread agreement that until now no pharmacological options are available to tackle the entire spectrum of clinical manifestations observed in PCOS [21]

However, the mechanisms underlying these effects have not been fully elucidated, with some preclinical studies revealing inconsistent results (20)

[2], the median time to reach nadir weight loss was 2 years after a Roux-en-Y gastric bypass (RYGB)

[DOI] [PubMed] [Google Scholar] 95.Hernandez AF, Green JB, Janmohamed S, et al

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This concern is theoretical for retatrutide specifically, as long-term bone density data are not yet available