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Use of Selenium in GO Over the last few years, in addition to the most common treatment for the management of moderate-to-severe and active GO, namely high dose oral and intravenous glucocorticoids (GC), orbital irradiation and surgical procedures (58), other medications have been proven effective to various extents, including rituximab (59), the recently FDA-approved teprotumumab (60, 61), mycophenolate (62), and tocilizumab (63)