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In the TGA system: Category B : Assigned when human data is unavailable, with subcategories based on animal study results: B1 : No evidence of foetal harm in animals

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The Evolution to Semaglutide and Modern Formulations Semaglutide represented a significant leap forward in GLP-1 technology, approved by the FDA in 2017 for type 2 diabetes under the brand name Ozempic

Methods Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) protocol recommendations were followed 13 and was registered at the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42016953346

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