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Comparative Efficacy and Safety of Glucagon Receptor Agonists on Metabolic Outcomes Network Meta-Analysis

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Over 99% achieved clinically meaningful weight loss, and nearly two-thirds lost more than 20% of their body weight

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On the other hand, in the SURMOUNT-1 trial with a similar dose-escalation and involving slightly younger and more overweight participants without T2D, a mean weight loss of up to 20.9% from baseline (17.8% difference from placebo in change in body weight) was reported after 72 weeks