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In a sample of 1,092 men and women without dementia followed for an average of 10 years, those with higher plasma homocysteine levels at baseline had a significantly higher risk of developing Alzheimer's disease and other types of dementia

The offspring from dams fed with mixed choline sources with lower free choline (12.5-25%) but high glycerophosphocholine (25-75%), exhibited a decrease in macrophage and dendritic cell frequencies in the spleen and produced less IL-1, IL-6 and IFN- in response to mitogenic immune challenge with either concanavalin A or LPS, compared to those from dams with higher free choline (100%) intake (87)

The relationship between GLP-1 receptor agonists like Ozempic and the immune system is an area of ongoing research, with emerging evidence suggesting potential immunomodulatory effects beyond glucose control

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In cardiac models, Bock-Marquette et al., Nature 2004 reported that T4 activates integrin-linked kinase and Akt signalling, promoting cardiomyocyte survival, migration and improved function after coronary ligation in mice