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[DOI] [Google Scholar] Feldman D

Pomegranate-derived compounds have been shown to modulate a wide range of molecular targets, including transcription factors, pro- and anti-apoptotic proteins, cell cycle regulators, protein kinases, cell adhesion molecules, pro-inflammatory mediators, and growth factors across multiple cancer types, such as skin, breast, prostate, colon, and lung cancers (366, 367)

Additionally, there is an upsurge in nitric oxide synthesis, activation of nuclear factor-B, an increase in nerve fiber density, elevated levels of serum C-reactive protein, and enhanced production of neuropeptide Y and nerve growth factor

A prospective controlled study showed that supplementation with 200ug SeMet per day during pregnancy and postpartum, reduced the incidence of PPTD and hypothyroidism (58)

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Treatment of the DMBA-induced rat mammary carcinoma by diabetes-induction with diazoxide