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J Am Geriatr Soc 71(4):205254

Key Players Benchmarking 2.3.1

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NAD+ affects mitochondrial function in several ways: It serves as an essential cofactor for dehydrogenases in the TCA cycle and electron transport chain [11] It supports SIRT3-mediated deacetylation of mitochondrial proteins, including Complex I (NDUFA9), Complex II (SDHA), and Complex III components [3] It activates PGC1, which regulates mitochondrial biogenesis [5] Age-related NAD+ decline affects these processes

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