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& Larijani, B

Initial dose adjustment is not required in patients with mild to moderate renal dysfunction

Oxidative stress, modified lipoproteins, and other lesion factors (bioactive lipids, pattern recognition molecules, cytokines) are capable of inducing inflammation via receptors (54,55,60)

In the future, we can anticipate more clinical trials targeting specific diseases with polyphenols, where their antioxidant and anti-inflammatory properties may be further utilized

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[27] demonstrated that LC and acetyl-LC undergo significant interconversion within the kidney, and the clearance of these generated compounds was approximately ten times higher than LC and acetyl- LC filtered directly from the circulation