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For symptoms potentially related to POTS or orthostatic intolerance , such as dizziness upon standing with palpitations, initially try conservative measures: rise slowly from sitting or lying positions, ensure adequate fluid intake (2-3 litres daily unless contraindicated), increase salt intake if appropriate (but only after consulting your doctor if you have hypertension, heart failure or kidney disease), and wear compression stockings

URAT1 is found on the basolateral membrane of these epithelial cells 42 , which suggests these two proteins are functioning in concert as transcellular UA transporters, as they do to achieve resorption in the kidney

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Given the lack of serious AEs and the possibility that the medication may benefit a subset of patients, the administration of oral hydroxyzine was designated as an Option

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