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These cytokines bind to IL-1R and can induce activity of SAM pointed domain containing ETS transcription factor (SPDEF) and other downstream regulators like anterior gradient 2 (AGR2) and endoplasmic reticulum to nucleus signaling 2 protein (ERN2) which mediate mucin folding (Chen et al., 2019

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Its anti-inflammatory profile is substantial, suppressing IL-6 and TNF-alpha, two of the cytokines most damaging during chronic neuroinflammation

Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis

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