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In human T cells, ChAT mRNA expression is induced via the activation of the PI3K signaling cascade (124)

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To date, TMA and TMNO have mostly been treated as nontoxic substances, but more recently, they have been treated as potentially carcinogenic agents, because of the possibility of their transformation into N-nitrosodimethylamine (NDMA) [57]

In response to stress, hepatocytes release pro-inflammatory mediators and damage-associated molecular patterns (DAMPs), leading to the activation and infiltration of immune cells, which further exacerbates hepatocyte damage

ChemRxiv , 2021, 17