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In vitro cytotoxicity assays using SH-SY5Y (human neuroblastoma), Caco-2 (intestinal permeability), and hCMEC/D3 (human brain endothelial) cells demonstrated that nanoencapsulation significantly reduced the inherent cytotoxicity of free coumarin

These potential cardioprotective effects may be related to the favourable actions of metformin on lipid metabolism, vascular smooth muscle, hypercoagulation, platelet hyperactivity, cardiomyocyte intracellular calcium handling and endothelial function [24]

doi: 10.1371/journal.pone.0132421 36 SteinE

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