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Clinical data suggests that 40 to 60% of weight loss can be regained within 1 to 2 years after stopping, though patients who maintain lifestyle modifications experience better long-term outcomes

In this context, Du et al., noted loss of tissue resident macrophages in colon biopsies from patients with ulcerative colitis, that was accompanied by decreased superoxide dismutase 2 expression (an important antioxidant) in the macrophages [3]

The FDA's adverse event reporting system has documented 489 reports of patients experiencing anxiety, depression, or suicidal thoughts while taking semaglutide medications, including 96 cases of suicidal thoughts [1]

That is a workforce that is paying close attention to how they are treated

Li et al., 2014)