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GLP-1 medications are typically initiated at low doses and increased slowly over several weeks or months, as per the product SmPC (Summary of Product Characteristics)

Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

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