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112 Pt 1 137146 (1999)

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Thus, from a structural biophysical point of view, this electrostatic repulsion could be explained by the two hydrogen bond-like electrostatic interactions (Table 5) and also the presence of a negatively charged Glu40 of GLP-1R ECD, which acts like an electrostatic connector for the two positively charged Arg123 and Arg127 of semaglutides backbone

Int J Obes (2007) 31(12):177785