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Graphic Abstract Our results clearly showed that LPS increased the cellular ROS by recognizing the TLR4 and H 2 O 2 rapidly increased the cellular (1) and mitochondrial (2) oxidative stress

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Fontan-Lozano A, Saez-Cassanelli JL, Inda MC, d et al (2007) Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor