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The study established that FOXO4 maintains senescent cell viability by targeting p53 to the nucleus and preventing apoptosis, and that disrupting the FOXO4-p53 interaction with FOXO4-DRI causes p53 nuclear exclusion and cell-intrinsic apoptosis in ionising radiation-induced and doxorubicin-induced senescent IMR90 fibroblasts

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Issue 8: pregnancy, breastfeeding and unstudied populations Active cosmetic ingredients without safety data in pregnancy or breastfeeding are conventionally avoided in those populations, and GHK-Cu falls into that category

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