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While the specific mechanism causing the effects on the gastrointestinal tract are not fully elucidated, studies suggest GLP-1 and its analogues likely exert effects on the vagus nerve and inhibit cholinergic neurotransmission in the gastrointestinal system to prevent movement of the intestine

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The largest published trial (METAOD006/OPTIONS) randomized 502 adults with obesity to AOD-9604 or placebo for 24 weeks alongside a diet and exercise program

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must be medically appropriate Tesamorelin is a highly targeted therapy, particularly effective for patients with fat redistribution concerns or metabolic health goals.

Here, we used primary hepatocytes and other metabolically active cell types to investigate the relationship between metabolic activity and ER stress