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It is mainly expressed in the PVN of the hypothalamus (PVH), the spinal cord, and sympathetic neurons

This sustained phase often involves periods of more rapid loss followed by brief stabilisation periods, which is normal and expected

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However, weight loss will eventually stabilize again as your body adapts to the new dose

You feel hungry so you eat, but your body doesnt send the Im full now signal properly, or it takes too long to send