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Agonist activities of AMG 133 were evaluated by measuring cAMP levels in CHO-K1 cells recombinantly expressing human or mouse GLP-1R or CHO-AM1D cells expressing cynomolgus monkey GLP-1R (Fig

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Elucidating the underlying cellular and molecular mechanisms could potentially usher in the development of new generations of incretin mimetics with enhanced efficacy and fewer adverse effects

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