This altered state features truncated carbohydrates known as T or Tn tumor antigens, among which Tn-MUC1, carrying Tn carbohydrates, emerges as a promising candidate for immunotherapy
Interestingly, in our sibling cohort we also observe that children with the most severe form of konzo (stage 3), have on average the lowest GPx3 levels as well as the largest difference when compared to unaffected siblings
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Furthermore, studies performed in endothelial cells, Kaposis sarcoma-associated herpesvirus (KSHV)-transformed cancer cells and several normal fibroblast or epithelial cell lines reported a similar effect of asparagine on supporting cell survival and protein translation after glutamine deprivation 44,49,50
108 , e1164e1174 (2023)
These figures come from a sponsor press release rather than a peer-reviewed manuscript, so they should be read as topline results pending full publication and independent scrutiny encouraging, and broadly consistent with the Phase 2 trajectory, but not yet the fully vetted dataset that regulators and clinicians ultimately rely on
