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This approach has been used to show that proteasome concentrations in peripheral blood are elevated in patients with certain types of malignant diseases, including multiple myeloma, suggesting that circulating proteasome levels may be correlated with tumour burden

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KIM-1 is a type I transmembrane protein molecule that is not detectable in healthy renal tissue, but is upregulated in de-differentiated proximal tubule epithelial cells after ischemic or toxic injury

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