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These medications slow down how quickly your stomach empties, which can lead to feelings of fullness, bloating, and nausea
Practical approaches: Start retatrutide at the lowest dose and titrate slowly Follow the recommended retatrutide titration schedule rather than jumping to high doses If weight loss exceeds 3 pounds per week consistently, consider slightly increasing caloric intake Ensure you are eating at least 1,200 calories daily, preferably 1,400-1,600 Do not skip meals even when appetite is suppressed The phase 2 trial data showed that starting at 2mg (rather than 4mg) significantly reduced GI side effects
In the stomach, it slows gastric emptying so food stays in your stomach longer
Quarterly visits during maintenance: weight check, lab review, plan adjustment
The medication also reduces cravings for high-calorie foods and increases the brain's recognition of satisfaction at smaller portion sizes, making it easier to maintain a calorie deficit without constant hunger
