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A review of English-language literature found fewer than 20 reported cases of nonmetastatic colonic EAC (Table 2)

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However, it is crucial to note that comprehensive human safety data remains limited, as most research has been conducted in animal models, primarily rodents

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(2003) on db/db diabetic and aged mice, and the Sosne corneal series (2002, 2005, 2010) form a coherent body of work demonstrating accelerated re-epithelialization, reduced inflammatory infiltration, and improved wound closure with topical, SC, or IM administration