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This contraindication reflects the theoretical concern that GLP-1 receptor stimulation could promote recurrence or progression of residual C-cell disease, even though human C-cells express minimal GLP-1 receptors

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However, similar to the glycemic control achieved with anti-diabetic drugs, there is little evidence on whether the weight reduction induced by anti-obesity drugs can decrease or postpone cardiovascular events in patients with obesity

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Do not change the concentration of a vial that has already been reconstituted