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The structure of the G q part of the 5-HT 2A complex (PDB: 6WHA) was used as initial models for model building of the ghrelin/GHRP-6 bound ghrelin receptorG q Nb35(scFv16) complex
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The supramammillary nucleus, located in the hypothalamus, is a new candidate that appears to be responsible for GLP-1 mediated anxiety effects because selective activation of GLP-1Rs in this nucleus by exendin-4 resulted in intensified anxiety-like behavior both in male and female rats