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Most of the abovementioned studies were conducted in individuals presumed to be healthy

Exclusion Criteria Insufficient Ischemia: rCBF reduction remaining above 30% of baseline, indicating failure to achieve the desired level of ischemia

( 10.1186/s12958-015-0032-1) [DOI] [PMC free article] [PubMed] [Google Scholar] Aitken RJ, Baker MA.2006

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The peptide is formulated at a target concentration and applied to the research area, achieving high local concentration without systemic distribution

The study also reported that over 95% of patients experienced side effects that were minimal or moderate but manageable, with only 3.3% reporting severe side effects during therapy