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Two things are worth underlining here

Existing evidence comes from case series showing modest metabolic benefit but minimal limb volume reduction

Research is ongoing into how these medications can be used for other health conditions, such as sleep apnea or cardiovascular health

[1] What we discovered, however, is that these arent actually two separate problems

(2020) 3:e2025850

Effects of Semaglutide With and Without Concomitant SGLT2 Inhibitor Use in Participants With Type 2 Diabetes and Chronic Kidney Disease in the FLOW Trial