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The most likely explanation for these surprise pregnancies is that significant weight loss from the drugs can restore ovulation, thus increasing the likelihood of pregnancy in obese women, many of whom do not ovulate spontaneously

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References 1 MukherjeeMStoddartAGuptaRPNwaruBIFarrAHeavenMet al

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In a 2021 study in obese mice, 5-amino-1MQ administration caused significant body mass reductions in the rodents, who achieved body composition and liver adiposity parameters that were comparable to the lean mice in the control group

When covered by BCBS, Wegovy generally requires prior authorization